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replication deficient aav2 virus  (Vector Biolabs)


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    Vector Biolabs replication deficient aav2 virus
    Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the <t>AAV2-GFP-Cre</t> construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.
    Replication Deficient Aav2 Virus, supplied by Vector Biolabs, used in various techniques. Bioz Stars score: 95/100, based on 15 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/replication deficient aav2 virus/product/Vector Biolabs
    Average 95 stars, based on 15 article reviews
    replication deficient aav2 virus - by Bioz Stars, 2026-03
    95/100 stars

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    1) Product Images from "Pannexin 1 sustains the electrophysiological responsiveness of retinal ganglion cells"

    Article Title: Pannexin 1 sustains the electrophysiological responsiveness of retinal ganglion cells

    Journal: Scientific Reports

    doi: 10.1038/s41598-018-23894-2

    Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the AAV2-GFP-Cre construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.
    Figure Legend Snippet: Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the AAV2-GFP-Cre construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.

    Techniques Used: Infection, Construct, Injection, MANN-WHITNEY



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    replication deficient aav2 virus  (Vector Biolabs)
    95
    Vector Biolabs replication deficient aav2 virus
    Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the <t>AAV2-GFP-Cre</t> construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.
    Replication Deficient Aav2 Virus, supplied by Vector Biolabs, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/replication deficient aav2 virus/product/Vector Biolabs
    Average 95 stars, based on 1 article reviews
    replication deficient aav2 virus - by Bioz Stars, 2026-03
    95/100 stars
    		  Buy from Supplier

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    Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the AAV2-GFP-Cre construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.

    Journal: Scientific Reports

    Article Title: Pannexin 1 sustains the electrophysiological responsiveness of retinal ganglion cells

    doi: 10.1038/s41598-018-23894-2

    Figure Lengend Snippet: Panx1 deficiency results in changes in RGC function. PERG responses were compared between C57Bl/6 wild-type (WT) and Panx1 −/− mice as described in Materials and Methods. ( A ) Box graphs of PERG responses in germline Panx1 −/− (Px1 KO). Left panel: PERG amplitude; right panel: PERG latency. n WT = 12; n KO = 12. ( B ) PERG response in RGCs with conditional Panx1 gene ablation. The recordings were performed 8 weeks after infection of the AAV2-GFP-Cre construct via intravitreal injection; n = 5. ( C ) Averaged waveforms of responses recorded from WT (white boxes), germline Panx1 −/− (Px1 KO, red), AAV2-EGFP-injected Panx1 fl/fl controls (AAV2-GFP, light blue) and conditional AAV2-Cre-EGFP –induced Panx1 RGC−/− (AAV2-Cre, dark blue) eyes. ***P < 0.001; **P < 0.01; significance: Mann Whitney test.

    Article Snippet: For RGC-selective deletion of the gene, Panx1 fl/fl mice received intraocular injection of a replication-deficient AAV2 virus carrying a CRE expression cassette (AAV2-Cre/GFP, Vector Biolabs, Philadelphia, PA), which transduced approximately 85–90% of the RGCs with only minimal transduction of some Müller cells (Schmitt et al . ).

    Techniques: Infection, Construct, Injection, MANN-WHITNEY